TRAINING RHESUS MACAQUES TO TAKE DAILY ORAL ANTIRETROVIRAL THERAPY FOR PRECLINICAL EVALUATION OF HIV PREVENTION AND TREATMENT STRATEGIES.

Training rhesus macaques to take daily oral antiretroviral therapy for preclinical evaluation of HIV prevention and treatment strategies.

BackgroundMacaque models of simian or simian/human immunodeficiency virus (SIV or SHIV) infection are critical for the evaluation of antiretroviral (ARV)-based HIV treatment and prevention strategies.However, modelling human oral ARV administration is logistically challenging and fraught by limited adherence.Here, we developed a protocol for admini

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The Role of Magmatic and Hydrothermal Fluids in the Formation of the Sasa Pb-Zn-Ag Skarn Deposit, Republic of Macedonia

The Sasa Pb-Zn-Ag deposit belongs to the group of distal base metal skarn deposits.The deposit is located within the Serbo-Macedonian massif, a metamorphosed crystalline terrain of Precambrian to Paleozoic age.The mineralization, hosted by Paleozoic marbles, shows a strong lithological control.It is spatially and temporally associated with the calc

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A train of blue light pulses delivered through closed eyelids suppresses melatonin and phase shifts the human circadian system

Mariana G Figueiro, Andrew Bierman, Mark S ReaLighting Research Center, Rensselaer Polytechnic Institute, Troy, NY, USAAbstract: A model of circadian phototransduction was published in 2005 to predict the spectral sensitivity of the human circadian system to narrow-band and polychromatic light sources by combining responses to light from the spectr

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